PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30591093-5 2018 We found that activation of HER2 and protein kinase B (AKT) were key factors in inducing intrinsic and acquired lapatinib-resistant gastric cancer cell lines, and that AUY922 effectively suppressed activation of both HER2 and AKT in acquired lapatinib-resistant gastric cancer cell lines. Lapatinib 112-121 AKT serine/threonine kinase 1 Homo sapiens 55-58 30591093-5 2018 We found that activation of HER2 and protein kinase B (AKT) were key factors in inducing intrinsic and acquired lapatinib-resistant gastric cancer cell lines, and that AUY922 effectively suppressed activation of both HER2 and AKT in acquired lapatinib-resistant gastric cancer cell lines. Lapatinib 242-251 AKT serine/threonine kinase 1 Homo sapiens 226-229