PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30521373-0 2019 MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex. Choline 32-39 microRNA 1295a Homo sapiens 0-15 30521373-2 2019 In this study, we demonstrated that cortical NPC self-renewal is controlled by choline via the expression of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which, in turn, inhibits synthesis of the epidermal growth factor receptor (EGFR) protein. Choline 79-86 epidermal growth factor receptor Homo sapiens 238-270 30521373-2 2019 In this study, we demonstrated that cortical NPC self-renewal is controlled by choline via the expression of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which, in turn, inhibits synthesis of the epidermal growth factor receptor (EGFR) protein. Choline 79-86 epidermal growth factor receptor Homo sapiens 272-276 30521373-3 2019 Specifically, we found that low choline (LC) availability led to the upregulation of miR-129-5p expression in cortical NPCs in vitro and in vivo, causing the downregulation of EGFR and thereby disrupting NPC self-renewal and cortical neurogenesis. Choline 32-39 microRNA 1295a Homo sapiens 85-95 30521373-3 2019 Specifically, we found that low choline (LC) availability led to the upregulation of miR-129-5p expression in cortical NPCs in vitro and in vivo, causing the downregulation of EGFR and thereby disrupting NPC self-renewal and cortical neurogenesis. Choline 32-39 epidermal growth factor receptor Homo sapiens 176-180