PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30520054-3 2019 In the present study, we examined the role of metformin in nuclear factor kappa B (NF-kappaB)-mediated inflammatory responses in HaCaT cells, a cell line for the keratinocyte. Metformin 46-55 nuclear factor kappa B subunit 1 Homo sapiens 59-81 30520054-3 2019 In the present study, we examined the role of metformin in nuclear factor kappa B (NF-kappaB)-mediated inflammatory responses in HaCaT cells, a cell line for the keratinocyte. Metformin 46-55 nuclear factor kappa B subunit 1 Homo sapiens 83-92 30520054-5 2019 Immunofluorescence staining and western blot analysis showed that metformin inhibited the nuclear localization of p65, a subunit of nuclear factor NF-kappaB. Metformin 66-75 nuclear factor kappa B subunit 1 Homo sapiens 147-156 30520054-6 2019 In addition, metformin suppressed the transcription activity of NF-kappaB by inhibiting the degradation of IkappaBalpha. Metformin 13-22 nuclear factor kappa B subunit 1 Homo sapiens 64-73 30520054-7 2019 The inhibitory effect of metformin on NF-kappaB signalling is comparable with a specific IKKbeta inhibitor BI605906. Metformin 25-34 nuclear factor kappa B subunit 1 Homo sapiens 38-47