PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30517913-0	2018	Expression Levels of the Tyrosine Hydroxylase Gene and Histone Modifications Around its Promoter in the Locus Coeruleus and Ventral Tegmental Area of Rats during Forced Abstinence from Morphine.	Morphine	185-193	tyrosine hydroxylase	Rattus norvegicus	25-45	
30517913-2	2018	We studied whether morphine-induced changes in mRNA levels of the catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are associated with histone modifications around the promoter of this gene in the locus coeruleus (LC) and ventral tegmental area (VTA) of rats.	Morphine	19-27	tyrosine hydroxylase	Rattus norvegicus	101-121	
30517913-2	2018	We studied whether morphine-induced changes in mRNA levels of the catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are associated with histone modifications around the promoter of this gene in the locus coeruleus (LC) and ventral tegmental area (VTA) of rats.	Morphine	19-27	tyrosine hydroxylase	Rattus norvegicus	123-125	
30517913-5	2018	RESULTS: Analysis of our real-time quantitative reverse transcription PCR results by 1-way ANOVA showed significant upregulation (5.13 +- 0.39 folds) of LC levels of the TH transcript 24 h after the last injection of morphine to rats, when compared with 2 h and 7 days time points.	Morphine	217-225	tyrosine hydroxylase	Rattus norvegicus	170-172	
30517913-7	2018	Consistently, chromatin immunoprecipitation real-time quantitative PCR assays revealed that 24 h after the last injection of morphine, levels of H3 acetylation were significantly increased (4.12 +- 0.38 folds) at the promoter of the TH gene in the LC but not in the VTA.	Morphine	125-133	tyrosine hydroxylase	Rattus norvegicus	233-235	
30517913-9	2018	CONCLUSIONS: Results of the present study, for the first time, demonstrate the involvement of histone H3 acetylation in the regulation of TH gene expression in the LC of rats during forced abstinence from morphine.	Morphine	205-213	tyrosine hydroxylase	Rattus norvegicus	138-140