PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30483760-1 2019 The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d- or l-forms of 2-hydroxyglutarate (2HG) from alpha-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 300-318 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-47 30483760-1 2019 The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d- or l-forms of 2-hydroxyglutarate (2HG) from alpha-ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 320-323 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-47