PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30464200-0	2018	Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis.	Bile Acids and Salts	23-32	fibroblast growth factor 15	Mus musculus	64-69	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	23-32	fibroblast growth factor 15	Mus musculus	233-260	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	23-32	fibroblast growth factor 15	Mus musculus	262-267	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	34-36	fibroblast growth factor 15	Mus musculus	233-260	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	34-36	fibroblast growth factor 15	Mus musculus	262-267	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	308-310	fibroblast growth factor 15	Mus musculus	233-260	
30464200-1	2018	Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesis in a negative feedback fashion.	Bile Acids and Salts	308-310	fibroblast growth factor 15	Mus musculus	262-267	
30464200-6	2018	Expression of the BA synthesis rate-limiting enzyme Cyp7a1 is reduced in FGF19-M52-treated mice compared to the GFP-treated control group with consequent reduction of BA pool and hepatic concentration.	Bile Acids and Salts	18-20	fibroblast growth factor 15	Mus musculus	73-78	
30464200-6	2018	Expression of the BA synthesis rate-limiting enzyme Cyp7a1 is reduced in FGF19-M52-treated mice compared to the GFP-treated control group with consequent reduction of BA pool and hepatic concentration.	Bile Acids and Salts	167-169	fibroblast growth factor 15	Mus musculus	73-78	
30464200-8	2018	Our data bona fide suggest the therapeutic potential of targeting the FXR-FGF19 axis to reduce hepatic BA synthesis in the control of BA-associated risk of fibrosis and hepatocarcinoma development.	Bile Acids and Salts	103-105	fibroblast growth factor 15	Mus musculus	74-79	
30464200-8	2018	Our data bona fide suggest the therapeutic potential of targeting the FXR-FGF19 axis to reduce hepatic BA synthesis in the control of BA-associated risk of fibrosis and hepatocarcinoma development.	Bile Acids and Salts	134-136	fibroblast growth factor 15	Mus musculus	74-79