PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30327544-0 2019 Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions. Saponins 21-29 ornithine aminotransferase pseudogene 1 Homo sapiens 63-68 30327544-4 2019 Inhibition of human OATP1B1/1B3 and rat Oatp1b2 by the individual saponins was investigated in vitro; the compounds" joint inhibition was also assessed in vitro and the data was processed using the Chou-Talalay method. Saponins 66-74 solute carrier organic anion transporter family member 1B1 Homo sapiens 20-31 30327544-9 2019 The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L). protopanaxadiol 4-19 solute carrier organic anion transporter family member 1B3 Homo sapiens 143-150 30327544-9 2019 The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L). Ginsenosides 25-37 solute carrier organic anion transporter family member 1B3 Homo sapiens 143-150 30327544-9 2019 The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L). Ginsenosides 25-36 solute carrier organic anion transporter family member 1B3 Homo sapiens 143-150 30327544-10 2019 Inhibition of OATP1B1 by ginsenosides was less potent than OATP1B3 inhibition. Ginsenosides 25-37 solute carrier organic anion transporter family member 1B1 Homo sapiens 14-21 30327544-11 2019 Ginsenosides Rb1, Rb2, Rc, Rd, Ro, Ra1, Re, and Rg2 likely contribute the major part of OATP1B3-mediated ShenMai-drug interaction potential, in an additive and time-related manner. Ginsenosides 0-12 RB transcriptional corepressor 1 Homo sapiens 13-16 30327544-11 2019 Ginsenosides Rb1, Rb2, Rc, Rd, Ro, Ra1, Re, and Rg2 likely contribute the major part of OATP1B3-mediated ShenMai-drug interaction potential, in an additive and time-related manner. Ginsenosides 0-12 RA1 Homo sapiens 35-38 30327544-11 2019 Ginsenosides Rb1, Rb2, Rc, Rd, Ro, Ra1, Re, and Rg2 likely contribute the major part of OATP1B3-mediated ShenMai-drug interaction potential, in an additive and time-related manner. Ginsenosides 0-12 solute carrier organic anion transporter family member 1B3 Homo sapiens 88-95