PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30273598-2 2018 We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells. 7-ketocholesterol 27-44 PYD and CARD domain containing Mus musculus 219-222