PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30239896-1 2018 RNase H1-dependent, phosphorothioate-modified antisense oligonucleotides (PS-ASOs) can enter cells through endocytic pathways and need to be released from the membrane-enclosed organelles, a limiting step for antisense activity. Parathion 20-36 ribonuclease H1 Homo sapiens 0-8 30239896-1 2018 RNase H1-dependent, phosphorothioate-modified antisense oligonucleotides (PS-ASOs) can enter cells through endocytic pathways and need to be released from the membrane-enclosed organelles, a limiting step for antisense activity. Oligonucleotides 56-72 ribonuclease H1 Homo sapiens 0-8 30239896-1 2018 RNase H1-dependent, phosphorothioate-modified antisense oligonucleotides (PS-ASOs) can enter cells through endocytic pathways and need to be released from the membrane-enclosed organelles, a limiting step for antisense activity. ps-asos 74-81 ribonuclease H1 Homo sapiens 0-8 30239896-8 2018 STX5 can re-locate to LEs upon PS-ASO incubation, can bind PS-ASOs, and the binding appears to be required for this pathway. Phosphorus 31-33 syntaxin 5 Homo sapiens 0-4 30239896-8 2018 STX5 can re-locate to LEs upon PS-ASO incubation, can bind PS-ASOs, and the binding appears to be required for this pathway. ps-asos 59-66 syntaxin 5 Homo sapiens 0-4 30239896-9 2018 Our study reveals a novel release pathway in which PS-ASO incubation causes LE re-localization of STX5, which mediates the recruitment of COPII vesicles to LEs to facilitate endosomal PS-ASO release, and identifies another key PS-ASO binding protein. ps-aso 51-57 syntaxin 5 Homo sapiens 98-102 30239896-9 2018 Our study reveals a novel release pathway in which PS-ASO incubation causes LE re-localization of STX5, which mediates the recruitment of COPII vesicles to LEs to facilitate endosomal PS-ASO release, and identifies another key PS-ASO binding protein. ps-aso 184-190 syntaxin 5 Homo sapiens 98-102 30239896-9 2018 Our study reveals a novel release pathway in which PS-ASO incubation causes LE re-localization of STX5, which mediates the recruitment of COPII vesicles to LEs to facilitate endosomal PS-ASO release, and identifies another key PS-ASO binding protein. Phosphorus 51-54 syntaxin 5 Homo sapiens 98-102