PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30219715-0	2018	Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.	Celecoxib	0-9	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	87-93	
30219715-0	2018	Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.	Celecoxib	46-55	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	87-93	
30219715-3	2018	In human liver microsomes (HLMs), a concentration-dependent inhibition of celecoxib hydroxylation by quinidine was observed after CYP2C9 and CYP3A4 were inhibited.	Celecoxib	74-83	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	130-136	
30219715-4	2018	In individual HLMs with variable CYP2D6 activities, a significant correlation was observed between celecoxib hydroxylation and CYP2D6-selective dextromethorphan O-demethylation when CYP2C9 and CYP3A4 activities were suppressed (r = 0.97, P < 0.0001).	Celecoxib	99-108	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	182-188	
30219715-8	2018	Using HLMs from individual donors, the relative contribution of CYP2D6 to celecoxib metabolism was found to be highly variable and dependent on CYP2C9 genotypes, ranging from no contribution in extensive metabolizers with CYP2C9*1*1 genotype to approximately 30% in slow metabolizers with allelic variants CYP2C9*1*3 and CYP2C9*3*3.	Celecoxib	74-83	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	144-150	
30219715-9	2018	These results demonstrate that celecoxib may become a potential victim of CYP2D6-associated drug-drug interactions, particularly in individuals with reduced CYP2C9 activity.	Celecoxib	31-40	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	157-163