PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30205091-2 2018 Methadone undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, CYP2C19, CYP2D6, CYP2C9, and CYP2C8. Methadone 0-9 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 96-102 30205091-3 2018 In vivo, polymorphism effects on methadone systemic exposure have been noted for CYP2B6, CYP3A4, and CYP2D6. Methadone 33-42 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 81-87