PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30116377-6 2018 In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells. Curcumin 13-21 AKT serine/threonine kinase 1 Homo sapiens 73-76 30116377-7 2018 In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway. Curcumin 15-23 AKT serine/threonine kinase 1 Homo sapiens 275-278