PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29958546-6 2018 Regional [18F]THK5351 standardized uptake value ratio (SUVR) in antemortem PET was significantly correlated with monoamine oxidase-B (MAO-B) level, reactive astrocytes density, and tau pathology at postmortem examination. THK5351 14-21 monoamine oxidase B Homo sapiens 113-132 29958546-6 2018 Regional [18F]THK5351 standardized uptake value ratio (SUVR) in antemortem PET was significantly correlated with monoamine oxidase-B (MAO-B) level, reactive astrocytes density, and tau pathology at postmortem examination. THK5351 14-21 monoamine oxidase B Homo sapiens 134-139 29958546-6 2018 Regional [18F]THK5351 standardized uptake value ratio (SUVR) in antemortem PET was significantly correlated with monoamine oxidase-B (MAO-B) level, reactive astrocytes density, and tau pathology at postmortem examination. THK5351 14-21 microtubule associated protein tau Homo sapiens 181-184 29958546-7 2018 In in vitro autoradiography, specific THK5351 binding was detected in the area of antemortem [18F]THK5351 retention, and binding was blocked completely by a reversible selective MAO-B inhibitor, lazabemide, in brain samples from these patients. THK5351 38-45 monoamine oxidase B Homo sapiens 178-183 29958546-8 2018 In conclusion, [18F]THK5351 PET signals reflect MAO-B expressing reactive astrocytes, which may be associated with tau accumulation in PSP. THK5351 20-27 monoamine oxidase B Homo sapiens 48-53 29958546-8 2018 In conclusion, [18F]THK5351 PET signals reflect MAO-B expressing reactive astrocytes, which may be associated with tau accumulation in PSP. THK5351 20-27 microtubule associated protein tau Homo sapiens 115-118