PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29857559-0 2018 The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia. RG7388 128-139 transformed mouse 3T3 cell double minute 2 Mus musculus 27-31 29857559-0 2018 The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia. RG7388 128-139 transformed mouse 3T3 cell double minute 2 Mus musculus 113-117 29857559-5 2018 Here we assessed the MDM2 antagonist idasanutlin and the MEK1 inhibitor cobimetinib as single agents and in combination in a variety of AML cell lines and primary AML blast cells for their ability to induce apoptosis and cell death. RG7388 37-48 transformed mouse 3T3 cell double minute 2 Mus musculus 21-25 29857559-9 2018 Our data indicate that AML cells with normal karyotype (NK) and wild-type status of TP53 with elevated FLT3 and MDM2 expression emerge to be most sensitive to the combined treatment with cobimetinib and idasanutlin. RG7388 203-214 transformed mouse 3T3 cell double minute 2 Mus musculus 112-116 29857559-10 2018 FLT3 and MDM2 are biomarkers for treatment response to idasanutlin and cobimetinib in AML. RG7388 55-66 transformed mouse 3T3 cell double minute 2 Mus musculus 9-13