PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29752428-2 2019 They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes. Triglycerides 101-114 lipoprotein lipase Mus musculus 24-42 29752428-4 2019 Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase. Triglycerides 139-151 angiopoietin-like 3 Mus musculus 59-66 29752428-4 2019 Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase. Cholesterol 156-167 angiopoietin-like 3 Mus musculus 59-66 29752428-8 2019 These observations have paved the way to the development of strategies to reduce the plasma level of atherogenic lipoproteins in man by the inactivation of ANGPTL3, using either a specific monoclonal antibody or anti-sense oligonucleotides. Oligonucleotides 223-239 angiopoietin like 3 Homo sapiens 156-163