PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29634344-2 2019 NAD+ depletion may occur in response to either excessive DNA damage due to free radical or ultraviolet attack, resulting in significant poly(ADP-ribose) polymerase (PARP) activation and a high turnover and subsequent depletion of NAD+, and/or chronic immune activation and inflammatory cytokine production resulting in accelerated CD38 activity and decline in NAD+ levels. NAD 0-4 CD38 molecule Homo sapiens 331-335