PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29572489-4 2018 Here, we report that Irp1 or Irp2-null mutation also causes downregulation of frataxin and IscU, two of the core components in the iron-sulfur cluster biogenesis machinery. Iron 131-135 iron-sulfur cluster assembly enzyme Homo sapiens 91-95 29572489-6 2018 Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality. Iron 103-107 iron-sulfur cluster assembly enzyme Homo sapiens 24-28