PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29526823-2 2018 The aim of this work was to test the efficacy of a complete EGFR-inhibition by osimertinib plus the monoclonal antibody cetuximab or the MEK1/2-inhibitor selumetinib in EGFR-mutated NCLC in vivo models. AZD 6244 154-165 epidermal growth factor receptor Homo sapiens 169-173 29526823-7 2018 CONCLUSIONS: We showed that a dual vertical EGFR blockade with osimertinib plus selumetinib/cetuximab is a novel effective therapeutic option in EGFR-mutated NCLC and that hedgehog pathway activation and its interplay with MAPK is involved in resistance to these combination treatments. AZD 6244 80-91 epidermal growth factor receptor Homo sapiens 145-149