PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29457866-6 2018 Metformin has also been reported to decrease expression of multiple histone methyltransferases, to increase the activity of the class III HDAC SIRT1 and to decrease the influence of DNMT inhibitors. Metformin 0-9 DNA methyltransferase 1 Homo sapiens 182-186