PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29381356-0	2018	Astaxanthin Induces the Nrf2/HO-1 Antioxidant Pathway in Human Umbilical Vein Endothelial Cells by Generating Trace Amounts of ROS.	astaxanthine	0-11	heme oxygenase 1	Homo sapiens	29-33	
29381356-5	2018	In addition, astaxanthin increased the mRNA levels of phase II enzymes HO-1 and also promoted GSH-Px enzyme activity.	astaxanthine	13-24	heme oxygenase 1	Homo sapiens	71-75	
29381356-7	2018	Knockdown of Nrf-2 by small interfering RNA inhibited HO-1 mRNA expression by 60%, indicating that the Nrf-2/ARE signaling pathway is activated by astaxanthin.	astaxanthine	147-158	heme oxygenase 1	Homo sapiens	54-58	
29381356-8	2018	Our results suggest that astaxanthin activates the Nrf-2/HO-1 antioxidant pathway by generating small amounts of ROS.	astaxanthine	25-36	heme oxygenase 1	Homo sapiens	57-61