PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29310291-0 2018 Fluorescence sensing platform based on ruthenium(II) complexes as high 3S (sensitivity, specificity, speed) and "on-off-on" sensors for the miR-185 detection. Ruthenium(II) 39-52 microRNA 185 Homo sapiens 140-147 29310291-1 2018 Inspired by the enormous importance attributed to the biological function of miRNA, we pour our attention into the design and synthesis of four ruthenium(II) complexes and evaluate their applications as miR-185 detection agents by spectroscopic measurements. Ruthenium(II) 144-157 microRNA 185 Homo sapiens 203-210 29310291-2 2018 It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min. 6-carboxyfluorescein 140-158 microRNA 185 Homo sapiens 104-111 29310291-2 2018 It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min. 6-carboxyfluorescein 140-158 Scm like with four mbt domains 1 Homo sapiens 244-248 29310291-2 2018 It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min. 6-carboxyfluorescein 140-158 doublecortin domain containing 2 Homo sapiens 261-265 29310291-3 2018 The results of the binding constant, fluorescence anisotropy (FA) and polyacrylamide gel electrophoresis experiments (PAGE) revealed that the ruthenium(II) complexes prefer to bind P-DNA other than hybrid duplexes DNA@RNA upon recognition, resulting in the detection of miR-185. Ruthenium 142-151 microRNA 185 Homo sapiens 270-277