PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29210568-1 2018 IscU, the central scaffold protein in the bacterial ISC iron-sulfur (Fe-S) cluster biosynthesis system, has long been recognized to bind a Zn2+ ion at its active site. Iron 69-73 iron-sulfur cluster assembly enzyme Homo sapiens 0-4 29210568-2 2018 While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis. Iron 178-182 iron-sulfur cluster assembly enzyme Homo sapiens 100-104 29210568-2 2018 While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis. Iron 178-182 iron-sulfur cluster assembly enzyme Homo sapiens 163-167 29210568-7 2018 Monitoring and comparing the conformational behavior and stabilization afforded by different transition metal ions upon IscU and SufU revealed similarities between the two proteins and suggest that metal-dependent conformational transitions may be characteristic of U-type proteins involved in Fe-S cluster biosynthesis. Iron 294-298 iron-sulfur cluster assembly enzyme Homo sapiens 120-124