PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29156743-1 2017 All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to induce p14 expression via promoter hypomethylation to activate the p14-MDM2-p53 pathway, which leads to activation of the p53-dependent apoptotic pathway and subsequent induction of apoptosis in human hepatoma cells. Tretinoin 0-23 tumor protein p53 Homo sapiens 174-177 29156743-1 2017 All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to induce p14 expression via promoter hypomethylation to activate the p14-MDM2-p53 pathway, which leads to activation of the p53-dependent apoptotic pathway and subsequent induction of apoptosis in human hepatoma cells. Tretinoin 0-23 tumor protein p53 Homo sapiens 220-223 29156743-1 2017 All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to induce p14 expression via promoter hypomethylation to activate the p14-MDM2-p53 pathway, which leads to activation of the p53-dependent apoptotic pathway and subsequent induction of apoptosis in human hepatoma cells. Tretinoin 25-29 tumor protein p53 Homo sapiens 174-177 29156743-1 2017 All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to induce p14 expression via promoter hypomethylation to activate the p14-MDM2-p53 pathway, which leads to activation of the p53-dependent apoptotic pathway and subsequent induction of apoptosis in human hepatoma cells. Tretinoin 25-29 tumor protein p53 Homo sapiens 220-223 29156743-2 2017 In the present study, we found that hepatitis C virus (HCV) Core derived from ectopic expression or HCV infection overcomes ATRA-induced apoptosis in p53-positive hepatoma cells. Tretinoin 124-128 tumor protein p53 Homo sapiens 150-153 29156743-6 2017 Based on these observations, we conclude that HCV Core executes its oncogenic potential by suppressing the p53-dependent apoptosis induced by ATRA in human hepatoma cells. Tretinoin 142-146 tumor protein p53 Homo sapiens 107-110