PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2910532-7 1989 The significantly lower COMT activity in the hamster liver and red blood cells suggests that under chronic estrogen treatment at high doses, the concentration of catechol estrogens in these tissues may exceed the capacity of COMT to effectively catalyse their O-methylation into inactive metabolites. catechol 162-170 catechol-O-methyltransferase Mus musculus 24-28