PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29048666-7 2017 Moreover, celecoxib enhanced the HDAC6 inhibitor-induced antitumor effects in PTEN-deficient U-87 MG cells that had been stably transfected with wild-type PTEN, but not in the same cell line stably transfected with mutant PTEN-K163R, which cannot be activated by HDAC6 inhibitors. Celecoxib 10-19 histone deacetylase 6 Homo sapiens 33-38 29048666-7 2017 Moreover, celecoxib enhanced the HDAC6 inhibitor-induced antitumor effects in PTEN-deficient U-87 MG cells that had been stably transfected with wild-type PTEN, but not in the same cell line stably transfected with mutant PTEN-K163R, which cannot be activated by HDAC6 inhibitors. Celecoxib 10-19 histone deacetylase 6 Homo sapiens 263-268 29048666-8 2017 In summary, the results indicated that the COX-2 inhibitor celecoxib enhanced the HDAC6 inhibitor-induced antitumor effects by activating the PTEN/AKT signaling pathway. Celecoxib 59-68 histone deacetylase 6 Homo sapiens 82-87