PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28993409-2 2017 The ibrutinib target, Bruton"s tyrosine kinase (BTK), is essential for B-cell receptor signaling, and most resistant cases carry mutations in BTK or PLCG2, a downstream effector target of BTK. ibrutinib 4-13 phospholipase C gamma 2 Homo sapiens 149-154