PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28939533-3 2017 This requires considering a set of experimentally validated protein targets in the folate pathway of major pathogenic trypanosomatid parasites and humans: (i) the primary parasite on-targets: pteridine reductase 1 (PTR1) (absent in humans) and bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), (ii) the primary off-targets: human DHFR and TS, and (iii) the secondary on-target: human folate receptor beta, a folate/antifolate transporter. Folic Acid 83-89 folate receptor beta Homo sapiens 403-423