PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28927780-7	2017	Metformin inhibited ERK1/2, JNK, and PI3K/Akt, but activated p38 pathway in these two cells.	Metformin	0-9	mitogen-activated protein kinase 8	Homo sapiens	28-31	
28927780-9	2017	The combination of specific inhibitors of ERK1/2, JNK or PI3K/Akt pathway and metformin further promoted cell apoptosis and the up-regulation of p21, Bax, Bad, cleaved caspase-3 and -9 as well as the down-regulation of Bcl-2 mediated by metformin alone, but inhibition of p38 pathway exhibited the opposite results.	Metformin	237-246	mitogen-activated protein kinase 8	Homo sapiens	50-53