PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28919480-5 2017 In the present study we found that reducing PM cholesterol results in the internalization of Orai1 channels, which can be prevented by overexpressing caveolin 1 (Cav1). Cholesterol 47-58 caveolin 1 Homo sapiens 150-160 28919480-5 2017 In the present study we found that reducing PM cholesterol results in the internalization of Orai1 channels, which can be prevented by overexpressing caveolin 1 (Cav1). Cholesterol 47-58 caveolin 1 Homo sapiens 162-166 28919480-7 2017 The effects of reducing cholesterol were not limited to an increased rate of Orai1 internalization, but also, affects the lateral movement of Orai1, inducing movement in a linear pattern (unobstructed diffusion) opposite to basal cholesterol conditions were most of Orai1 channels moves in a confined space, as assessed by Fluorescence Correlation Spectroscopy, Cav1 overexpression inhibited these alterations maintaining Orai1 into a confined and partially confined movement. Cholesterol 24-35 caveolin 1 Homo sapiens 362-366