PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28903339-5 2017 PI3K inhibitor ZSTK474 or STAT3 inhibitor Niclosamide not only abolished ING5 knockdown-promoted proliferation, colony formation, migration and invasion of lung cancer A549 cells, but also impaired ING5 knockdown-stimulated metastasis of cancer cells in mouse xenograft models with tail vein injection of A549 cells. Niclosamide 42-53 signal transducer and activator of transcription 3 Mus musculus 26-31 28903339-6 2017 Furthermore, treatment with ZSTK474 or Niclosamide decreased protein level of EGFR, p-Akt, IL-6 and p-STAT3, and reversed ING5 knockdown-promoted EMT, as indicated by downregulated expression of EMT marker E-cadherin, an epithelial marker, increased expression of N-cadherin, a mesenchymal marker, and EMT-related transcription factors including Snail, Slug, Smad3 and Twist. Niclosamide 39-50 signal transducer and activator of transcription 3 Mus musculus 102-107