PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28667034-4 2017 We assume that this amino acid substitution affects the enzymatic activity of ALAS2 by affecting its interaction with the cofactor pyridoxal 5"-phosphate, since the patient was responsive to pyridoxine treatment. Pyridoxal Phosphate 131-153 5'-aminolevulinate synthase 2 Homo sapiens 78-83