PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28608236-0	2017	The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway.	Nicotine	47-55	brain-derived neurotrophic factor	Rattus norvegicus	98-102	
28608236-12	2017	In addition, nicotine treatment increased lipid peroxidation and the levels of GSH, IL-1beta, TNF-alpha and Bax, while reducing Bcl-2, P-CREB and BDNF levels in the hippocampus.	Nicotine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	146-150	
28608236-15	2017	Thus, curcumin via activation of P-CREB/BDNF signaling pathway, confers neuroprotection against nicotine-induced inflammation, apoptosis and oxidative stress.	Nicotine	96-104	brain-derived neurotrophic factor	Rattus norvegicus	40-44