PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28553083-0 2017 Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells. Cisplatin 0-9 beclin 1 Homo sapiens 61-66 28553083-11 2017 The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Cisplatin 135-144 microtubule associated protein 1 light chain 3 alpha Homo sapiens 14-17 28553083-11 2017 The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Cisplatin 135-144 nucleoporin 62 Homo sapiens 35-38 28553083-11 2017 The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Cisplatin 135-144 microtubule associated protein 1 light chain 3 alpha Homo sapiens 64-67 28553083-12 2017 Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of cisplatin toward BC cells. Cisplatin 14-23 autophagy related 7 Homo sapiens 63-67 28553083-12 2017 Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of cisplatin toward BC cells. Cisplatin 14-23 autophagy related 12 Homo sapiens 68-73 28553083-12 2017 Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of cisplatin toward BC cells. Cisplatin 120-129 autophagy related 7 Homo sapiens 63-67 28553083-12 2017 Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of cisplatin toward BC cells. Cisplatin 120-129 autophagy related 12 Homo sapiens 68-73 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 66-75 beclin 1 Homo sapiens 33-41 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 66-75 beclin 1 Homo sapiens 43-48 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 137-146 beclin 1 Homo sapiens 33-41 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 137-146 beclin 1 Homo sapiens 108-113 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 137-146 beclin 1 Homo sapiens 33-41 28553083-14 2017 Mechanistically, upregulation of beclin-1 (BECN1) was detected in cisplatin-treated cells, and knockdown of BECN1 using shRNA attenuated cisplatin-induced autophagy and subsequently enhanced cisplatin-induced apoptosis. Cisplatin 137-146 beclin 1 Homo sapiens 108-113 28553083-15 2017 CONCLUSION: Collectively, the study results indicated that cisplatin-induced autophagy is mediated by BECN1 in BC cells. Cisplatin 59-68 beclin 1 Homo sapiens 102-107