PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28515684-0 2017 Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson"s Disease. Selegiline 0-10 bone marrow stromal cell antigen 1 Mus musculus 68-73 28515684-0 2017 Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson"s Disease. Selegiline 0-10 bone marrow stromal cell antigen 1 Mus musculus 74-78 28515684-2 2017 Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and is widely used in the treatment of PD and major depression. Selegiline 0-10 monoamine oxidase B Mus musculus 30-49 28515684-2 2017 Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and is widely used in the treatment of PD and major depression. Selegiline 0-10 monoamine oxidase B Mus musculus 51-56 28515684-5 2017 A single administration of selegiline (1-10 mg/kg) dose-dependently reduced immobility time in the forced swimming test (FST) in CD157 KO mice, but not C57BL/6N wild-type (WT) mice. Selegiline 27-37 bone marrow stromal cell antigen 1 Mus musculus 129-134 28515684-6 2017 At 10 mg/kg, but not 3 mg/kg, selegiline significantly increased climbing time in CD157 KO mice. Selegiline 30-40 bone marrow stromal cell antigen 1 Mus musculus 82-87 28515684-9 2017 After the FST, CD157 KO mice showed decreases in striatal and hippocampal serotonin (5-HT) content, cortical norepinephrine (NE) content, and plasma corticosterone concentration. Serotonin 74-83 bone marrow stromal cell antigen 1 Mus musculus 15-20 28515684-9 2017 After the FST, CD157 KO mice showed decreases in striatal and hippocampal serotonin (5-HT) content, cortical norepinephrine (NE) content, and plasma corticosterone concentration. Norepinephrine 109-123 bone marrow stromal cell antigen 1 Mus musculus 15-20 28515684-9 2017 After the FST, CD157 KO mice showed decreases in striatal and hippocampal serotonin (5-HT) content, cortical norepinephrine (NE) content, and plasma corticosterone concentration. Corticosterone 149-163 bone marrow stromal cell antigen 1 Mus musculus 15-20 28515684-11 2017 In the open field test (OFT), repeated administration of mirtazapine had anxiolytic effects, and selegiline nonsignificantly ameliorated anxiety-like behaviors in CD157 KO mice. Selegiline 97-107 bone marrow stromal cell antigen 1 Mus musculus 163-168 28515684-12 2017 In the social interaction and preference tests, repeated mirtazapine ameliorated the high anxiety and low sociability of CD157 KO mice, whereas selegiline did not. Mirtazapine 57-68 bone marrow stromal cell antigen 1 Mus musculus 121-126 28515684-13 2017 These results indicate that selegiline has antidepressant and mild anxiolytic effects in CD157 KO mice, and suggest that it is an effective antiparkinsonian drug for depressive and anxiety symptoms in PD patients with a CD157 single nucleotide polymorphism (SNP). Selegiline 28-38 bone marrow stromal cell antigen 1 Mus musculus 89-94 28515684-13 2017 These results indicate that selegiline has antidepressant and mild anxiolytic effects in CD157 KO mice, and suggest that it is an effective antiparkinsonian drug for depressive and anxiety symptoms in PD patients with a CD157 single nucleotide polymorphism (SNP). Selegiline 28-38 bone marrow stromal cell antigen 1 Homo sapiens 220-225