PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28398250-3	2017	However, it is not clear why Shiga toxin 1 (Stx1) or Shiga toxin 2 (Stx2) holotoxin is not active in a cell-free system.	stichoposide	74-83	syntaxin 2	Homo sapiens	68-72	
28398250-4	2017	Here, we compare the ribosome binding and depurination activity of Stx1 and Stx2 holotoxins with the A1 subunits of Stx1 and Stx2 using either the ribosome or a 10-mer RNA mimic of the sarcin/ricin loop as substrates.	stichoposide	81-91	syntaxin 2	Homo sapiens	76-80	
28398250-5	2017	Our results demonstrate that the active sites of Stx1 and Stx2 holotoxins are blocked by the A2 chain and the B subunit, while the ribosome binding sites are exposed to the solvent.	stichoposide	63-73	syntaxin 2	Homo sapiens	58-62	
28398250-6	2017	Unlike ricin, which is enzymatically active, but cannot interact with the ribosome, Stx1 and Stx2 holotoxins are enzymatically inactive but can interact with the ribosome.	stichoposide	98-108	syntaxin 2	Homo sapiens	93-97