PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28336180-0 2017 An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT). Cholesterol 99-110 solute carrier family 10 member 2 Homo sapiens 175-182 28336180-0 2017 An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT). Cholesterol 99-110 solute carrier family 10 member 2 Homo sapiens 183-187 28336180-3 2017 Previous studies revealed that regulation of the ASBT involves BAs and cholesterol. Cholesterol 71-82 solute carrier family 10 member 2 Homo sapiens 49-53 28336180-4 2017 In addition, abnormal ASBT expression and function might lead to some diseases associated with disorders in the enterohepatic circulation of BAs and cholesterol homeostasis, such as diarrhoea and gallstones. Cholesterol 149-160 solute carrier family 10 member 2 Homo sapiens 22-26 28336180-5 2017 However, decreasing cholesterol or BAs by partly inhibiting ASBT-mediated transport might be used for treatments of hypercholesterolemia, cholestasis and diabetes. Cholesterol 20-31 solute carrier family 10 member 2 Homo sapiens 60-64 28336180-6 2017 This review mainly discusses the regulation of the ASBT by BAs and cholesterol and its relevance to diseases and treatment. Cholesterol 67-78 solute carrier family 10 member 2 Homo sapiens 51-55