PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28222070-11 2017 This was mediated by reduced expression of histone deacetylase 6 (HDAC6), which further inhibited the phosphorylation of Akt and the expression of thymidylate synthase (TYMS), the critical determinant of 5-FU cytotoxicity. Fluorouracil 204-208 histone deacetylase 6 Homo sapiens 43-64 28222070-11 2017 This was mediated by reduced expression of histone deacetylase 6 (HDAC6), which further inhibited the phosphorylation of Akt and the expression of thymidylate synthase (TYMS), the critical determinant of 5-FU cytotoxicity. Fluorouracil 204-208 histone deacetylase 6 Homo sapiens 66-71