PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28186963-7 2017 In addition, B392 enhanced the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells through inhibition of Akt/mTOR pathway and Mcl-1 protein expression, and also was active in the p-glycoprotein (p-gp)-overexpressing National Cancer Institute/Adriamycin-Resistant cells with little susceptibility to p-gp. Sirolimus 47-56 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 144-149