PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28077325-0 2017 Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR. Paclitaxel 64-74 stratifin Homo sapiens 8-20 28077325-1 2017 In this study, we presented the role of 14-3-3sigma to activate CK2-Hsp90beta-PXR-MDR1 pathway on rifampin and paclitaxel treated LS174T cells and in vivo LS174T cell-xenografted nude mouse model. Paclitaxel 111-121 stratifin Homo sapiens 40-51 28077325-10 2017 P-gp overexpression was induced only when 14-3-3sigma transfected LS174T cells were treated with rifampin and paclitaxel, whereas 14-3-3sigma inhibition by nonpeptidic inhibitor, BV02 and 14-3-3sigma siRNA reduced rifampin induced PXR and P-gp expression. Paclitaxel 110-120 stratifin Homo sapiens 42-53 28077325-12 2017 This data indicates that 14-3-3sigma contributes to P-gp overexpression through interaction with PXR with rifampin and paclitaxel treatment. Paclitaxel 119-129 stratifin Homo sapiens 25-36