PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27983649-1 2016 Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a-p)) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification on the aniline moiety of vandetanib. vandetanib 324-334 epidermal growth factor receptor Homo sapiens 14-46 27983649-2 2016 Preliminary biological tests showed that comparing with vandetanib, some target compounds exhibited excellent EGFR inhibitory activities and anti-proliferative over A549/H446 cells in hypoxia. vandetanib 56-66 epidermal growth factor receptor Homo sapiens 110-114