PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27773789-1 2016 Decreased thiamine and reduced activity of thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase (OGDH) cause neurodegeneration. Thiamine Pyrophosphate 43-63 oxoglutarate dehydrogenase Rattus norvegicus 111-115 27773789-1 2016 Decreased thiamine and reduced activity of thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase (OGDH) cause neurodegeneration. Thiamine Pyrophosphate 65-69 oxoglutarate dehydrogenase Rattus norvegicus 111-115 27773789-4 2016 According to the data, the astrocytic OGDH may be up-regulated by an increase in intracellular ThDP, while the neuroblastomal OGDH functions at full ThDP saturation. Thiamine Pyrophosphate 95-99 oxoglutarate dehydrogenase Rattus norvegicus 38-42 27773789-4 2016 According to the data, the astrocytic OGDH may be up-regulated by an increase in intracellular ThDP, while the neuroblastomal OGDH functions at full ThDP saturation. Thiamine Pyrophosphate 149-153 oxoglutarate dehydrogenase Rattus norvegicus 126-130 27773789-6 2016 Increased ThDP level in response to the OGDH inhibition presumably up-regulated the enzyme to compensate for a decrease in reducing power which occurred in SP-treated astrocytes. Thiamine Pyrophosphate 10-14 oxoglutarate dehydrogenase Rattus norvegicus 40-44