PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27694321-0 2016 Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Ticagrelor 105-115 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 42-46 27694321-4 2016 This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. Ticagrelor 26-36 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 120-158 27694321-4 2016 This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. Ticagrelor 26-36 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 160-164 27694321-4 2016 This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. Ticagrelor 94-104 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 120-158 27694321-4 2016 This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. Ticagrelor 94-104 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 160-164 27694321-11 2016 In summary, our studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation. Ticagrelor 60-70 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 95-99