PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27599706-4 2017 METHODS: This study predicted the magnitude of the DDI between efavirenz, an inducer of CYP3A4 and inhibitor of CYP2C8, and dual CYP3A4/CYP2C8 substrates (repaglinide, montelukast, pioglitazone, paclitaxel) using a physiologically based pharmacokinetic (PBPK) modeling approach integrating concurrent effects on CYPs. montelukast 168-179 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 136-142