PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27559163-15 2016 We found that mutant huntingtin protein (mHtt) at the endogenous level decreases BDNF secretion from astrocytes by disrupting the conversion of GTP-Rab3a into GDP-Rab3a and that overexpressing Rab3a can rescue this deficient BDNF release and early neuropathology in HD knock-in mouse brain. Guanosine Triphosphate 144-147 huntingtin Mus musculus 21-31