PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27555492-0	2016	Insights into kinetic mechanism of Janus kinase 3 and its inhibition by tofacitinib.	tofacitinib	72-83	Janus kinase 3	Homo sapiens	35-49	
27555492-2	2016	The studies presented in this report were undertaken to elucidate the kinetic mechanism of the JAK3 kinase domain, investigate the role of activation loop phosphorylation in regulating its catalytic activity, and examine its inhibition by the anti-rheumatoid arthritis drug, tofacitinib.	tofacitinib	275-286	Janus kinase 3	Homo sapiens	95-99	
27555492-9	2016	Kinetic analysis of JAK3 inhibition by tofacitinib indicated inhibition is time dependent, characterized by on- and off-rate constants of 1.4 +- 0.1 muM-1s-1 and 0.0016 +- 0.0005 s-1, respectively.	tofacitinib	39-50	Janus kinase 3	Homo sapiens	20-24