PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27424921-8 2016 We also found that nicotine induced phosphatidylinositol 3-kinase (PI3K) signal activation, and a specific inhibitor of the nicotine acetylcholine receptor (nAChR) as well as knockdown of nAChR prevented nicotine-mediated Akt phosphorylation and aPKC activation. Nicotine 19-27 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 36-65