PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26697169-8 2015 Furthermore, exposure of HLMVECs to HGF or S1P stimulated c-Abl-mediated tyrosine phosphorylation of paxillin at Y31 and Y118 in a time-dependent fashion, and down-regulation of c-Abl with siRNA attenuated HGF- or S1P-mediated lamellipodia formation, translocation of p47 (phox) to lamellipodia, and endothelial barrier enhancement. Tyrosine 73-81 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 58-63 26697169-10 2015 Together, these results suggest that c-Abl-mediated tyrosine phosphorylation of paxillin at Y31 and Y118 regulates HGF- or S1P-mediated lamellipodia formation, ROS generation in lamellipodia, and endothelial permeability. Tyrosine 52-60 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 37-42