PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26621843-7 2016 Furthermore, a specific inhibitor of Akt, but not Src, significantly enhanced lapatinib-mediated anti-proliferative/anti-survival effects on SKBR3-pool2 and BT474-HR20 cells. Lapatinib 78-87 AKT serine/threonine kinase 1 Homo sapiens 37-40 26621843-8 2016 These data indicate that erbB3 signaling is critical for both trastuzumab and lapatinib resistances mainly through the PI-3K/Akt pathway, whereas IGF-1R-initiated Src activation results in trastuzumab resistance without affecting lapatinib sensitivity. Lapatinib 78-87 AKT serine/threonine kinase 1 Homo sapiens 125-128