PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26607110-0	2016	miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells.	Lactic Acid	35-42	hexokinase 2	Homo sapiens	76-87	
26607110-4	2016	Using bioinformatic databases, we predicted that hexokinase2 (HK2), a rate-limiting enzyme in the glycolytic pathway, was a target of miR-4458, so the effects of miR-4458 on glycolysis and lactate production was assessed in colon cancer cells.	Lactic Acid	189-196	hexokinase 2	Homo sapiens	49-60	
26607110-4	2016	Using bioinformatic databases, we predicted that hexokinase2 (HK2), a rate-limiting enzyme in the glycolytic pathway, was a target of miR-4458, so the effects of miR-4458 on glycolysis and lactate production was assessed in colon cancer cells.	Lactic Acid	189-196	hexokinase 2	Homo sapiens	62-65	
26607110-8	2016	Moreover, knockdown of HK2 by specific RNAi also suppressed proliferation, glycolysis, and lactate production under both normoxic and hypoxic conditions.	Lactic Acid	91-98	hexokinase 2	Homo sapiens	23-26	
26607110-9	2016	In conclusion, our findings suggested that miR-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA.	Lactic Acid	132-139	hexokinase 2	Homo sapiens	174-177