PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26359313-2 2015 Previous preclinical studies have implicated alpha4beta2 and alpha7 nAChRs as potential mediators of the antinociceptive effects of (-)-nicotine hydrogen tartrate (nicotine) and other nAChR agonists; however, these studies have relied exclusively on measures of pain-stimulated behavior, which can be defined as behaviors that increase in frequency, rate, or intensity after presentation of a noxious stimulus. Nicotine 136-144 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 68-73